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Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Gene name. HMGCR : Synonyms. Description.

This is confuted by the fact that peroxisomal HMGCR is recognized not only in the catalytic domain but also at epitopes in the membrane-spanning region by several of the same antibodies as the ER enzyme. Hmgcr: Description: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Source:MGI Symbol;Acc:MGI:96159] Organism: Mus musculus: Synonym(s) 3-hydroxy-3-methylglutaryl-coa reductase, g3x8u5, hmg-coar, q5u4i2, red: Orthologs(s) 24 orthologs The Function of HMGCR Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. The gene view histogram is a graphical view of mutations across HMGCR.

Blood lipid genetic scores, the HMGCR gene and cancer risk

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Gene name. HMGCR : Synonyms. Description.

2021-01-22 · Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease. Xueyan Zhao, Jiawen Li, Xiaofang Tang, Ru Liu, Jingjing Xu, Lianjun Xu, Lin Jiang, Keyong Huang, Jian Tian, Xinxing Feng, Yajie Wu, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, 2011-01-31 · Hmgcr endogenous gene expression studies: possible mechanisms for differential transcript abundance. Tissue distribution pattern of the Hmgcr gene showed a high level of expression in the liver . Consistently, the Hmgcr protein level was reported to be 4- to 6 -fold higher in the liver than most peripheral tissues . Proteomics products related to HMGCR Gene Other products related to HMGCR such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com genomics-online.com Variants in the HMGCR gene region, which represent proxies for statin treatment, were associated with overall cancer risk (odds ratio [OR] per one standard deviation decrease in low-density lipoprotein [LDL] cholesterol 0.76, 95% confidence interval [CI] 0.65–0.88, p=0.0003) but variants in gene regions representing alternative lipid-lowering treatment targets (PCSK9, LDLR, NPC1L1, APOC3 18 Sep 2012 In mammalian genomes, only one gene encodes the HMGCR enzyme, which mainly resides in the membrane of the endoplasmic reticulum[19, The first gene implicated in the production or activity of an attractant by the SGPs was hmgcr (columbus), which encodes HMGCoA reductase (Van Doren, 1998). In 26 Mar 2009 To study the role of genetic variation in the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR) gene in polycystic ovary HUGO Gene Nomenclature Committee (HGNC) approved gene symbol report for HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) reductase (HMGCR) gene, the rate-limiting enzyme in cho- lesterol biosynthesis, and the target of LDL-C lowering statin drugs.
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Sequencing of 21 Aug 2019 Regulatory mechanism of HMGCR. The human HMGCR gene (GeneID: 3156) is located on chromosome 5q12, and it encodes three isoforms ( 1 Sep 2011 Background and objectives Experimental acute kidney injury (AKI) activates the HMG–CoA reductase (HMGCR) gene, producing proximal tubule 13 Sep 2016 Similarly, using RT-qPCR, the statin-induced feedback up-regulation of four selected cholesterol biosynthesis genes (HMGCR, HMGCS1, MVD 3-hydroxy-3-methylglutaryl-CoA reductase. Target Gene.

However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays. All these results indicate that the change in the expression of the HMGCR protein during the cholesterol and lovastatin feeding is a result of sterol-mediated modulation of its degradation. HMGCR: Description: 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] Organism: Homo sapiens: Synonym(s) b7z3y9, ldlcq3, q8n190 2021-03-06 · Cholesterol synthesis was blocked in culture by inhibiting the activity of HMG CoA reductase (HMGCR) resulting in germ cell survival and migration defects renal ischemia/reperfusion activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading. Gene name.
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8, MUT, ddPCR hg19, chr5, 65, Yes. 597, CNV, HMGCR, HEX, hg19, chr5, 65, Yes. Few viruses have affected humanity as much as IAV We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and surgery, biopsies were taken from the liver for histology and gene as well of lipid turnover (SREBP2, SCD, HMGCR) were reflected by Obesity-linked genes' regulation in Drosophila melanogaster In D. melanogaster the regulation of Twz, TfAp2, Hmgcr and G9a were significantly affected by (HMG-CoA) reduktas (HMGCR, det hastighetsbegränsande enzymet i C.-Y. et al. Microbiota prevents cholesterol loss from the body by regulating host gene Estradiolnivåer för höga mödrar i serum inducerar dyslipidemi hos humana nyfödda via ett hepatiskt HMGCR-östrogenresponselement. ämnen Prediktiva och beta-hydroxi-beta-metylglutaryl-CoA-reduktas (HMGCR), viktiga enzymer "Entrez Gene: PRKAB2 proteinkinas, AMP-aktiverat, beta 2 icke-katalytisk in the Tubb4a gene leads to microtubule accumulation with hypomyelination and 1474 dagar, Pathogenic role of anti-SRP and anti-HMGCR antibodies in Celltypspecifik RNAi av Hmgcr med användning av DY-635 [NP] (siHMGCR) The effects of siHMGCR#2 on gene expression were assessed in 8 × 10 5 Few viruses have affected humanity as much as IAV We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and HMG-CoA-reduktas(HMGCR) *Hastighetsbestämmande steg i kolesterol de-novo-syntes *Aktiveras av insulin, hämmas av glukagon och adrenalin *Lever, tarm Correlation of expression of lncRNAs and protein-coding gene neighbors på liknande sätt och involverade i myelinering 17, inklusive Hmgcr, Hmgcs1 och stages of tumorigensis, TGFbeta acquires tumor promoting activities We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, HLRCC · Klinisk genetik och genomik · HLXB9 · Klinisk genetik och genomik · HMGCR ak · Klinisk immunologi och transfusionsmedicin · HMMA · Klinisk kemi.

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The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers. HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase (human) HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial Hyperlipidemia and Sitosterolemia. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Regulation of cholesterol biosynthesis by SREBP (SREBF). Cholesterol synthesis was blocked in culture by inhibiting the activity of HMG CoA reductase (HMGCR) resulting in germ cell survival and migration defects renal ischemia/reperfusion activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading.

Made to Order. Catalog # 1320001 20 nmol; Price: See in cart Your Price: Online offer: Check your price › Add To Cart Add to Array HMGCR Gene Expression in HepG2 Cell Lines (Sarang Burung Wale t (EBN) Berdos Tinggi Meningkatkan LDL-R melalui Perencatan Gen HMGCR dalam Sel HepG2) MOHD NOOR AKMAL, ABDUL RAZAK INTAN-SHAMEHA, ROZAIHAN MANSOR, AINI IDERIS, ABDUL RAHMAN OMAR, JALILA ABU, MOHD FAIZ IDRIS & MOKRISH AJAT* 2012-03-20 HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. (52) Additional Compounds for HMGCR Gene - From: Novoseek, HMDB, and Tocris (3S)-3-Hydroxy-3-methylglutaryl-coenzyme A (S)-3-Hydroxy-3-methylglutaryl-coenzyme A 3-Hydroxy-3-methylglutaryl-CoA HMG-CoA HMG-coenzyme A HMGCR gene variation is associated with multiple lipid/lipoprotein traits, especially with triglyceride. The impact of the genetic variance is modest and differs greatly among ethnicities. Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD. HMGCR protein expression summary.